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9 warning signs of PFIC liver disease
Progressive Familial Intrahepatic Cholestasis (PFIC) is a rare and challenging liver disorder affecting individuals across the globe. This genetic condition disrupts the normal flow of bile from the liver, leading to many health complications. PFIC is primarily caused by mutations in genes responsible for bile transport proteins, which impair the liver’s ability to excrete bile properly. As a result, individuals with PFIC experience a variety of symptoms. Some of the warning signs to look out for include: Persistent jaundice Jaundice, characterized by a yellowing of the eyes and skin, is a key indicator of liver dysfunction. In PFIC, this discoloration persists due to the impaired bile flow from the liver. Bile contains bilirubin, a pigment formed during the breakdown of red blood cells. When the liver cannot effectively excrete bilirubin, it accumulates in the bloodstream, causing the distinctive yellow hue associated with jaundice. Pruritus The intense itching experienced by individuals with PFIC is a consequence of elevated bile acids in the skin. These acids accumulate due to impaired bile flow, triggering a maddening itch that can significantly impact daily life and sleep. The constant scratching may lead to skin damage, creating a challenging cycle for those grappling with this symptom.
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